Chronic Rhinosinusitis

2000

• Kern RC. Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa. Laryngoscope. 2000 Jul; 110(7): 1071-7. (UPSIT)

2001

• Seiden AM, Duncan HJ. The diagnosis of a conductive olfactory loss. Laryngoscope. 2001 Jan; 111(1): 9-14. (UPSIT)

2002

• Sugiyama K, Matsuda T, Kondo H, Mitsuya S, Hashiba M, Murakami S, Baba S. Postoperative olfaction in chronic sinusitis: smokers versus nonsmokers. Ann Otol Rhinol Laryngol. 2002 Nov;111(11):1054-8. (UPSIT)

2006

• Sugiyama K, Hasegawa Y, Sugiyama N, Suzuki M, Watanabe N, Murakami S. Smoking-induced olfactory dysfunction in chronic sinusitis and assessment of brief University of Pennsylvania Smell Identification Test and T&T methods. Am J Rhinol. 2006 Sep-Oct; 20(5): 439-44. (UPSIT)

2008

• Jiang RS, Lu FJ, Liang KL, Shiao JY, Su MC, Hsin CH, Chen WK. Olfactory function in patients with chronic rhinosinusitis before and after functional endoscopic sinus surgery. Am J Rhinol. 2008 Jul-Aug; 22(4): 445-8. (UPSIT; STT)
• Litvack JR, Fong K, Mace J, James KE, Smith TL. Predictors of olfactory dysfunction in patients with chronic rhinosinusitis. Laryngoscope. 2008 Dec; 118(12): 2225-30. (UPSIT)

2009

• Litvack JR, Mace JC, Smith TL. Olfactory function and disease severity in chronic rhinosinusitis. Am J Rhinol Allergy. 2009 Mar-Apr; 23(2): 139-44. (UPSIT)
• Guss J, Doghramji L, Reger C, Chiu AG. Olfactory dysfunction in allergic rhinitis. ORL J Otorhinolaryngol Relat Spec. 2009; 71(5): 268-72. (UPSIT)
• Soler ZM, Sauer DA, Mace J, Smith TL. Relationship between clinical measures and histopathologic findings in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2009 Oct; 141(4): 454-61. (UPSIT)

2010

• Soler ZM, Hwang PH, Mace J, Smith TL. Outcomes after middle turbinate resection: revisiting a controversial topic. Laryngoscope. 2010 Apr; 120(4): 832-7. (UPSIT)
• Soler ZM, Sauer DA, Mace JC, Smith TL. Ethmoid histopathology does not predict olfactory outcomes after endoscopic sinus surgery. Am J Rhinol Allergy. 2010 Jul-Aug; 24(4): 281-5. (UPSIT)

2011

• Kim DW, Kim JY, Jeon SY. The status of the olfactory cleft may predict postoperative olfactory function in chronic rhinosinusitis with nasal polyposis. Am J Rhinol Allergy. 2011 Mar-Apr; 25(2): e90-4. (CC-SIT)

2014

• Alt JA, Mace JC, Buniel MC, Soler ZM, Smith TL. Predictors of olfactory dysfunction in rhinosinusitis using the brief smell identification test. Laryngoscope. 2014 Jan 8. doi: 10.1002/lary.24587. (B-SIT)
• DeConde AS, Mace JC, Alt JA, Schlosser RJ, Smith TL, Soler ZM. Comparative effectiveness of medical and surgical therapy on olfaction in chronic rhinosinusitis: a prospective, multi-institutional study. Int Forum Allergy Rhinol. 2014 Sep;4(9):725-33. doi: 10.1002/alr.21350. Epub 2014 Jul 12. (BSIT)
• Liu JJ, Chan GC, Hecht AS, Storm DR, Davis GE. Nasal saline irrigation has no effect on normal olfaction: a prospective randomized trial. Int Forum Allergy Rhinol. 2014 Jan;4(1):39-42. doi: 10.1002/alr.21235. PMID: 24574085; PMCID: PMC4085125. (UPSIT)

2015

• Kim BG, Oh JH, Choi HN, Park SY. Simple assessment of olfaction in patients with chronic rhinosinusitis. Acta Otolaryngol. 2015 Mar;135(3):258-63. doi: 10.3109/00016489.2014.974288. Epub 2015 Jan 27. (BSIT)
• Soler ZM, Hyer JM, Ramakrishnan V, Smith TL, Mace J, Rudmik L, Schlosser RJ. Identification of chronic rhinosinusitis phenotypes using cluster analysis. Int Forum Allergy Rhinol. 2015 May;5(5):399-407. doi: 10.1002/alr.21496. Epub 2015 Feb 17. Erratum in: Int Forum Allergy Rhinol. 2017 Jan;7(1):106. PMID: 25694390; PMCID: PMC4428937. (BSIT)
• Soler ZM, Pallanch JF, Sansoni ER, Jones CS, Lawrence LA, Schlosser RJ, Mace JC, Smith TL. Volumetric computed tomography analysis of the olfactory cleft in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015 Sep;5(9):846-54. doi: 10.1002/alr.21552. Epub 2015 May 26. PMID: 26010298; PMCID: PMC4560663. (UPSIT)
• Kuperan AB, Lieberman SM, Jourdy DN, Al-Bar MH, Goldstein BJ, Casiano RR. The effect of endoscopic olfactory cleft polyp removal on olfaction. Am J Rhinol Allergy. 2015 Jul;29(4):309-13. doi: 10.2500/ajra.2015.29.4191. (UPSIT)
• Rawal RB, Deal AM, Ebert CS Jr, Dhandha VH, Mitchell CA, Hang AX, Gore MR, Senior BA, Zanation AM. Post-operative budesonide irrigations for patients with polyposis: a blinded, randomized controlled trial. Rhinology. 2015 Sep 1;53(3):227-234. (UPSIT)

2016

• Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, Hellings P, Jiao L, Wang L, Evans RR, Pirozzi G, Graham NM, Swanson B, Hamilton JD, Radin A, Gandhi NA, Stahl N, Yancopoulos GD, Sutherland ER. Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial. JAMA. 2016 Feb 2;315(5):469-79. doi: 10.1001/jama.2015.19330. (UPSIT)
• Kohli P, Naik AN, Farhood Z, Ong AA, Nguyen SA, Soler ZM, Schlosser RJ. Olfactory Outcomes after Endoscopic Sinus Surgery for Chronic Rhinosinusitis: A Meta-analysis. Otolaryngol Head Neck Surg. 2016 Dec;155(6):936-948. doi: 10.1177/0194599816664879. Epub 2016 Aug 30. PMID: 27576679. (BSIT)
• Kohli P, Naik AN, Harruff EE, Nguyen SA, Schlosser RJ, Soler ZM. The prevalence of olfactory dysfunction in chronic rhinosinusitis. Laryngoscope. 2017 Feb;127(2):309-320. doi: 10.1002/lary.26316. Epub 2016 Nov 22. PMID: 27873345; PMCID: PMC5258829. (UPSIT, BSIT)
• Levy JM, Mace JC, Sansoni ER, Soler ZM, Smith TL. Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis. Int Forum Allergy Rhinol. 2016 Nov;6(11):1188-1195. doi: 10.1002/alr.21800. Epub 2016 May 24. (BSIT)
• El Rassi E, Mace JC, Steele TO, Alt JA, Soler ZM, Fu R, Smith TL. Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2016 Mar;6(3):287-92. doi: 10.1002/alr.21670. Epub 2015 Dec 1. PMID: 26625169; PMCID: PMC4783276. (BSIT)

2017

• Ramakrishnan VR, Mace JC, Soler ZM, Smith TL. Examination of high-antibiotic users in a multi-institutional cohort of chronic rhinosinusitis patients. Int Forum Allergy Rhinol. 2017 Apr;7(4):343-351. doi: 10.1002/alr.21903. Epub 2017 Jan 13. PMID: 28084683; PMCID: PMC5386802. (BSIT)
• Schlosser RJ, Storck KA, Rudmik L, Smith TL, Mace JC, Mattos J, Soler ZM. Association of olfactory dysfunction in chronic rhinosinusitis with economic productivity and medication usage. Int Forum Allergy Rhinol. 2017 Jan;7(1):50-55. doi: 10.1002/alr.21841. Epub 2016 Aug 23. (UPSIT)
• Lavin J, Min JY, Lidder AK, Huang JH, Kato A, Lam K, Meen E, Chmiel JS, Norton J, Suh L, Mahdavinia M, Hulse KE, Conley DB, Chandra RK, Shintani-Smith S, Kern RC, Schleimer RP, Tan BK. Superior turbinate eosinophilia correlates with olfactory deficit in chronic rhinosinusitis patients. Laryngoscope. 2017 Oct;127(10):2210-2218. doi: 10.1002/lary.26555. Epub 2017 Mar 21. PMID: 28322448; PMCID: PMC5607065. (UPSIT)
• Levy JM, Mace JC, Bodner TE, Alt JA, Smith TL. Defining the minimal clinically important difference for olfactory outcomes in the surgical treatment of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2017 Aug;7(8):821-826. doi: 10.1002/alr.21964. Epub 2017 May 26. PMID: 28556611; PMCID: PMC5544549. (BSIT)
• Turner JH, Wu J, Dorminy CA, Chandra RK. Safety and tolerability of surfactant nasal irrigation. Int Forum Allergy Rhinol. 2017 Aug;7(8):809-812. doi: 10.1002/alr.21959. Epub 2017 May 30. PMID: 28558139. (UPSIT)
• Hauser LJ, Chandra RK, Li P, Turner JH. Role of tissue eosinophils in chronic rhinosinusitis-associated olfactory loss. Int Forum Allergy Rhinol. 2017 Oct;7(10):957-962. doi: 10.1002/alr.21994. Epub 2017 Jul 25. PMID: 28742240; PMCID: PMC5624838. (UPSIT)
• Beswick DM, Mace JC, Chowdhury NI, Alt JA, Hwang PH, DeConde AS, Smith TL. Comparison of surgical outcomes between patients with unilateral and bilateral chronic rhinosinusitis. Comparison of surgical outcomes between patients with unilateral and bilateral chronic rhinosinusitis. Int Forum Allergy Rhinol. 2017 Dec;7(12):1162-1169. doi: 10.1002/alr.22020. Epub 2017 Sep 22. (BSIT)

2018

• Wu J, Chandra RK, Li P, Hull BP, Turner JH. Olfactory and middle meatal cytokine levels correlate with olfactory function in chronic rhinosinusitis. Laryngoscope. 2018 Sep;128(9):E304-E310. doi: 10.1002/lary.27112. Epub 2018 Feb 8. PMID: 29417576; PMCID: PMC6082743. (UPSIT)
• Ooi ML, Richter K, Bennett C, Macias-Valle L, Vreugde S, Psaltis AJ, Wormald PJ. Topical Colloidal Silver for the Treatment of Recalcitrant Chronic Rhinosinusitis. Front Microbiol. 2018 Apr 11;9:720. doi: 10.3389/fmicb.2018.00720. eCollection 2018. (UPSIT)
• Wang JJ, Chen J, Doty RL. Impact of antibiotics on smell dysfunction. World J Otorhinolaryngol Head Neck Surg. 2018 Jun 5;4(1):33-38. (UPSIT)
• Morse JC, Shilts MH, Ely KA, Li P, Sheng Q, Huang LC, Wannemuehler TJ, Chowdhury NI, Chandra RK, Das SR, Turner JH. Patterns of olfactory dysfunction in chronic rhinosinusitis identified by hierarchical cluster analysis and machine learning algorithms. Int Forum Allergy Rhinol. 2019 Mar;9(3):255-264. doi: 10.1002/alr.22249. Epub 2018 Nov 28. PMID: 30485725; PMCID: PMC6397071. (UPSIT)
• Beswick DM, Mace JC, Rudmik L, Soler ZM, Alt JA, Smith KA, Detwiller KY, Smith TL. Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019 Mar;9(3):231-239. doi: 10.1002/alr.22256. Epub 2018 Dec 10. PMID: 30548212; PMCID: PMC6397069. (BSIT)
• Yousefi J, Madarshahi H, Akhavan A, Taheri A, Saeedi M, Bagherihagh A, Hosseini MA, Khosravi MH. Effect of ESS on Olfactory Threshold of Patients with CRS without Nasal Polyps. Int Tinnitus J. 2018 Jun 1;22(1):89-92. doi: 10.5935/0946-5448.20180015. PMID: 29993224. (STT)
• Shehata EM, Tomoum MO, Amer MA, Alarabawy RA, Eltomey MA. Olfactory bulb neuroplasticity: A prospective cohort study in patients with chronic rhinosinusitis with nasal polyps. Clin Otolaryngol. 2018 Dec;43(6):1528-1534. doi: 10.1111/coa.13202. Epub 2018 Aug 23. PMID: 30058179. (UPSIT)

2019

• Bachert C, Zinreich SJ, Hellings PW, Mullol J, Hamilos DL, Gevaert P, Naclerio RM, Amin N, Joish VN, Fan C, Zhang D, Staudinger H, Pirozzi G, Graham NMH, Khan A, Mannent LP. Dupilumab reduces opacification across all sinuses and related symptoms in patients with CRSwNP. Rhinology. 2020 Feb 1;58(1):10-17. doi: 10.4193/Rhin18.282. PMID: 31671432. (PSIT)
• Ooi ML, Jothin A, Bennett C, Ooi EH, Vreugde S, Psaltis AJ, Wormald PJ. Manuka honey sinus irrigations in recalcitrant chronic rhinosinusitis: phase 1 randomized, single-blinded, placebo-controlled trial. Int Forum Allergy Rhinol. 2019 Dec;9(12):1470-1477. doi: 10.1002/alr.22423. Epub 2019 Aug 28. (UPSIT)

2020

• Bachert C, Zinreich SJ, Hellings PW, Mullol J, Hamilos DL, Gevaert P, et al. Dupilumab reduces opacification across all sinuses and related symptoms in patients with CRSwNP. Rhinology. 2020 Feb 1;58(1):10-17. (UPSIT)
• Beswick DM, Smith TL, Mace JC, Alt JA, Farrell NF, et al. Ethmoid-to-maxillary opacification ratio: a predictor of postoperative olfaction and outcomes in nasal polyposis? Int Forum Allergy Rhinol. 2020 Jun 18. (BSIT)
• Zhao R, Chen K, Tang Y. Olfactory changes after endoscopic sinus surgery for chronic rhinosinusitis: a meta-analysis. Clin Otolaryngol. 2020 Aug 31. (UPSIT)
• Mustafa SS, Vadamalai K, Scott B, Ramsey A. Dupilumab as Add-on Therapy for Chronic Rhinosinusitis With Nasal Polyposis in Aspirin Exacerbated Respiratory Disease. Am J Rhinol Allergy. 2020 Sep 23;1945892420961969. (UPSIT)
• Endam LM, Alromaih S, Gonzalez E, Madrenas J, Cousineau B, Renteria AE, Desrosiers M. Intranasal Application of Lactococcus lactis W136 Is Safe in Chronic Rhinosinusitis Patients With Previous Sinus Surgery. Front Cell Infect Microbiol. 2020 Oct 12;10:440. (UPSIT)

2021

• Farrell NF, Mace JC, Sauer DA, Thomas AJ, Geltzeiler M, Detwiller KY, Smith TL. Mucosal Eosinophilia and Neutrophilia Are Not Associated With QOL or Olfactory Function in Chronic Rhinosinusitis. Am J Rhinol Allergy. 2021 Jan 11;1945892420987439. (BSIT)
• Peters AT, Han JK, Hellings P, Heffler E, Gevaert P, Bachert C, et al. Indirect Treatment Comparison of Biologics in Chronic Rhinosinusitis with Nasal Polyps. J Allergy Clin Immunol Pract. 2021 Feb 3;S2213-2198(21)00159-8. (UPSIT)
• Beswick DM, Smith TL, Mace JC, Alt JA, Farrell NF, Ramakrishnan VR, Schlosser RJ, Soler ZM. Ethmoid-to-maxillary opacification ratio: a predictor of postoperative olfaction and outcomes in nasal polyposis? Int Forum Allergy Rhinol. 2021 Jan;11(1):48-57. (BSIT)
• Zhao R, Chen K, Tang Y. Olfactory changes after endoscopic sinus surgery for chronic rhinosinusitis: A meta-analysis. Clin Otolaryngol. 2021 Jan;46(1):41-51. (UPSIT)
• Tversky J, Lane AP, Azar A. Benralizumab Effect on Severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP): A Randomized Double Blind Placebo Controlled Trial. Clin Exp Allergy. 2021 Feb 17. (UPSIT)
• Hopkins C, Wagenmann M, Bachert C, Desrosiers M, Han JK, Hellings PW, et al. Efficacy of dupilumab in patients with a history of prior sinus surgery for chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2021 Feb 21. (UPSIT)
• El Rassi E, Mace JC, Steele TO, Alt JA, Soler ZM, Fu R, Smith TL. Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2016 Mar;6(3):287-92. (BSIT)
• Mustafa SS, Vadamalai K, Scott B, Ramsey A. Dupilumab as Add-on Therapy for Chronic Rhinosinusitis With Nasal Polyposis in Aspirin Exacerbated Respiratory Disease. Am J Rhinol Allergy. 2021 May;35(3):399-407. (UPSIT)
• Ta NH, Gao J, Philpott C. A systematic review to examine the relationship between objective and patient-reported outcome measures in sinonasal disorders: recommendations for use in research and clinical practice. Int Forum Allergy Rhinol. 2021 May;11(5):910-923. (UPSIT)
• Damask C, Chen M, Holweg CTJ, Yoo B, Millette LA, Franzese C. Defining the Efficacy of Omalizumab in Nasal Polyposis: A POLYP 1 and POLYP 2 Subgroup Analysis. Am J Rhinol Allergy.2021 Aug 12;19458924211030486. (UPSIT)
• Agache I, Song Y, Alonso-Coello P, Vogel Y, Rocha C, et al. Efficacy and safety of treatment with biologicals for severe chronic rhinosinusitis with nasal polyps: A systematic review for the EAACI guidelines. Allergy. 2021 Aug;76(8):2337-2353. (UPSIT)
• Mullol J, Bachert C, Amin N, Desrosiers M, Hellings PW, Han JK, Jankowski R, Vodicka J, Gevaert P, Daizadeh N, Khan AH, Kamat S, Patel N, Graham NMH, Ruddy M, Staudinger H, Mannent LP. Olfactory Outcomes with Dupilumab in Chronic Rhinosinusitis with Nasal Polyps. J Allergy Clin Immunol Pract. 2021 Oct 7:S2213-2198(21)01104-1. doi: 10.1016/j.jaip.2021.09.037. Epub ahead of print. PMID: 34628065.
• Ninan S, Goldrich DY, Liu K, Kidwai S, McKee S, Williams L, Del Signore A, Govindaraj S, Iloreta AM. Long Term Olfactory Outcomes Following Frontal Sinus Surgery in Chronic Rhinosinusitis. Laryngoscope. 2021 Oct;131(10):2173-2178. doi: 10.1002/lary.29513. Epub 2021 Mar 22. PMID: 33749867.
• Jiang RS, Shih KH, Liang KL. Effect of Functional Endoscopic Sinus Surgery on Gustatory Function in Patients With Chronic Rhinosinusitis. Ear Nose Throat J. 2021 May 12:1455613211015754. doi: 10.1177/01455613211015754. Epub ahead of print. PMID: 33977765. (UPSIT-C)
• Bertlich M, Ihler F, Bertlich I, Weiss BG, Gröger M, Haubner F. Management of chronic rhinosinusitis with nasal polyps in Samter triad by low-dose ASA desensitization or dupilumab. Medicine (Baltimore). 2021 Oct 8;100(40):e27471. doi: 10.1097/MD.0000000000027471. PMID: 34622875; PMCID: PMC8500659. (BSIT)

2022

• Wu Q, Zhang Y, Kong W, Wang X, Yuan L, Zheng R, Qiu H, Huang X, Yang Q. Which Is the Best Biologic for Nasal Polyps: Dupilumab, Omalizumab, or Mepolizumab? A Network Meta-Analysis. Int Arch Allergy Immunol. 2022;183(3):279-288. doi: 10.1159/000519228. Epub 2021 Oct 4. PMID: 34607329.
• Chuang CC, Guillemin I, Bachert C, Lee SE, Hellings PW, Fokkens WJ, Duverger N, Fan C, Daizadeh N, Amin N, Mannent LP, Khan AH, Kamat S. Dupilumab in CRSwNP: Responder Analysis Using Clinically Meaningful Efficacy Outcome Thresholds. Laryngoscope. 2022 Feb;132(2):259-264. doi: 10.1002/lary.29911. Epub 2021 Nov 24. PMID: 34817082.
• Han JK, Bachert C, Lee SE, Hopkins C, Heffler E, Hellings PW, Peters AT, Kamat S, Whalley D, Qin S, Nelson L, Siddiqui S, Khan AH, Li Y, Mannent LP, Guillemin I, Chuang CC. Estimating Clinically Meaningful Change of Efficacy Outcomes in Inadequately Controlled Chronic Rhinosinusitis with Nasal Polyposis. Laryngoscope. 2022 Feb;132(2):265-271. doi: 10.1002/lary.29888. Epub 2021 Dec 1. PMID: 34850966.
• Wang Q, Sun Q, Chen Q, Li H, Liu D, Wu Q. Efficacy and Safety of Anti-Interleukin-5 Therapies in Chronic Rhinosinusitis with Nasal Polyps: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int Arch Allergy Immunol. 2022 Feb 2:1-12. doi: 10.1159/000521859. Epub ahead of print. PMID: 35108711.
• Olonisakin TF, Moore JA, Barel S, Uribe B, Parker D, Bowers EMR, Nouraie SM, Wenzel SE, Lee SE. Fractional Exhaled Nitric Oxide as a Marker of Mucosal Inflammation in Chronic Rhinosinusitis. Am J Rhinol Allergy. 2022 Mar 3:19458924221080260. doi: 10.1177/19458924221080260. Epub ahead of print. PMID: 35238663. (UPSIT)
• Gevaert P, Saenz R, Corren J, Han JK, Mullol J, Lee SE, Ow RA, Zhao R, Howard M, Wong K, Islam L, Ligueros-Saylan M, Omachi TA, Bachert C. Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study. J Allergy Clin Immunol. 2022 Mar;149(3):957-965.e3. doi: 10.1016/j.jaci.2021.07.045. Epub 2021 Sep 14. PMID: 34530020. (UPSIT)
• Price CPE, Guo A, Stevens WW, Cousens L, Vu TT, Suh LA, Erickson KA, Conley D, Grammer LC, Kern RC, Tan BK, Kato A, Schleimer RP, Smith SS, Welch KC, Peters AT. Efficacy of an oral CRTH2 antagonist (AZD1981) in the treatment of chronic rhinosinusitis with nasal polyps in adults: A randomized controlled clinical trial. Clin Exp Allergy. 2022 Jul;52(7):859-867. doi: 10.1111/cea.14158. Epub 2022 May 18. PMID: 35524339. (B-SIT)
• Cai S, Xu S, Lou H, Zhang L. Comparison of Different Biologics for Treating Chronic Rhinosinusitis With Nasal Polyps: A Network Analysis. J Allergy Clin Immunol Pract. 2022 Jul;10(7):1876-1886.e7. doi: 10.1016/j.jaip.2022.02.034. Epub 2022 Mar 8. PMID: 35272073. (UPSIT)
• Jeong SS, Chen T, Nguyen SA, Edwards TS, Schlosser RJ. Correlation of polyp grading scales with patient symptom scores and olfaction in chronic rhinosinusitis: a systematic review and meta-analysis. Rhinology. 2022 Apr 19. doi: 10.4193/Rhin22.011. Epub ahead of print. PMID: 35438689. (UPSIT)
• Canonica GW, Bourdin A, Peters AT, Desrosiers M, Bachert C, Weidinger S, Simpson EL, Daizadeh N, Chen Z, Kamat S, Khan AH, Chao J, Graham NMH, Laws E, Rossi AB, Ardeleanu M, Mannent LP, Amin N, Ortiz B, Deniz Y, Djandji M, Rowe PJ. Dupilumab Demonstrates Rapid Onset of Response Across Three Type 2 Inflammatory Diseases. J Allergy Clin Immunol Pract. 2022 Jun;10(6):1515-1526. doi: 10.1016/j.jaip.2022.02.026. Epub 2022 Mar 6. PMID: 35259535. (UPSIT)
• Trimarchi M, Vinciguerra A, Rampi A, Tanzini U, Nonis A, Yacoub MR, Bussi M. A prospective study on the efficacy of dupilumab in chronic rhinosinusitis with type 2 inflammation. Acta Otorhinolaryngol Ital. 2022 Dec;42(6):538-544. doi: 10.14639/0392-100X-N2156. PMID: 36654520; PMCID: PMC9853107. (BSIT)
• Gevaert P, Bachert C, Maspero JF, Cuevas M, Steele D, Acharya S, Altman P. Phase 3b randomized controlled trial of fevipiprant in patients with nasal polyposis with asthma (THUNDER). J Allergy Clin Immunol. 2022 May;149(5):1675-1682.e3. doi: 10.1016/j.jaci.2021.12.759. Epub 2022 Jan 29. PMID: 35094848. (UPSIT)

2023

• Schneider S, Poglitsch K, Morgenstern C, Quint T, Gangl K, Sinz C, Bartosik T, Campion NJ, Liu DT, Landegger LD, Tu A, Stanek V, Rocha-Hasler M, Bangert C, Eckl-Dorna J. Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease. Eur Respir J. 2023 Mar 16;61(3):2201335. doi: 10.1183/13993003.01335-2022. PMID: 36549708; PMCID: PMC10017890. (UPSIT)
• Busse WW, Pavord ID, Siddiqui S, Khan AH, Praestgaard A, Nash S, Jacob-Nara JA, Rowe PJ, Deniz Y. Dupilumab Improves Outcomes in Patients with Chronic Rhinosinusitis with Nasal Polyps and Coexisting Asthma Irrespective of Baseline Asthma Characteristics. J Asthma Allergy. 2023 Apr 18;16:411-419. doi: 10.2147/JAA.S391896. PMID: 37096015; PMCID: PMC10122472. (UPSIT)
• Zhang Y, Yan B, Shen S, Song X, Jiang Y, Shi L, Zhao C, Yang Y, Jiang L, Li J, Ye J, Liu J, Wan L, Yang Y, Chen J, Liu F, Su L, Xu Y, Tan G, Yu S, Zhang Y, Wang L, Liu S, Yan H, Liu W, Chen B, Wang C, Zhang L. Efficacy and safety of CM310 in severe eosinophilic chronic rhinosinusitis with nasal polyps (CROWNS-1): a multicentre, randomised, double-blind, placebo-controlled phase 2 clinical trial. EClinicalMedicine. 2023 Jul 5;61:102076. doi: 10.1016/j.eclinm.2023.102076. PMID: 37483544; PMCID: PMC10359732. (UPSIT)
• Lee SE, Amin N, Mannent LP, Bachert C, Gross G, Cho SH, Praestgaard A, Siddiqui S, Nash S, Kamat S, Khan AH, Jacob Nara JA. The relationship of sinus opacification, olfaction and dupilumab efficacy in patients with CRSwNP. Rhinology. 2023 Jul 15. doi: 10.4193/Rhin22.220. Epub ahead of print. PMID: 37453138. (UPSIT)
• Zucoloto NN, Aguiar FS, Lopes NMD, Garcia ECD, Romano FR, Bezerra TFP, Lima WTA, Fornazieri MA. Exploring the impact of inflammatory endotypes on olfactory function and quality of life in chronic rhinosinusitis patients. Braz J Otorhinolaryngol. 2023 Nov 20;90(2):101364. doi: 10.1016/j.bjorl.2023.101364. Epub ahead of print. PMID: 38039618; PMCID: PMC10711166. (UPSIT)

2024

• Mullol J, Lund VJ, Wagenmann M, Han JK, Sousa AN, Smith SG, Mayer B, Chan RH, Fokkens WJ. Mepolizumab improves sense of smell in severe chronic rhinosinusitis with nasal polyps: SYNAPSE. Rhinology. 2024 Jan 13. doi: 10.4193/Rhin22.416. Epub ahead of print. PMID: 38217844. (UPSIT)
• Fornazieri MA, Garcia ECD, Montero RH, Borges R, Bezerra TFP, Pinna FR, Doty RL, Voegels RL. Prevalence and Magnitude of Olfactory Dysfunction in Allergic Rhinitis. Am J Rhinol Allergy. 2024 May 17:19458924241253642. doi: 10.1177/19458924241253642. Epub ahead of print. PMID: 38759958. (UPSIT)
• Fokkens WJ, Bachert C, Hopkins C, Marglani O, Praestgaard A, Nash S, Deniz Y, Rowe PJ, Sacks H, Jacob-Nara JA. Dupilumab improves outcomes in patients with chronic rhinosinusitis with nasal polyps irrespective of gender: results from the SINUS-52 trial. Clin Transl Immunology. 2024 Jun 8;13(6):e1511. doi: 10.1002/cti2.1511. PMID: 38854740; PMCID: PMC11161870. (UPSIT)
• Maniaci A, Bonacci P, Stefani S, Cocuzza S, Merlino F, Saibene AM, Sangiorgio G, Maza-Solano J, Lechien JR, La Mantia I, Musso N. Influence of Single Nucleotide Polymorphisms on CRS Outcomes: A Preliminary Observational Study. Laryngoscope. 2024 Aug 22. doi: 10.1002/lary.31719. Epub ahead of print. PMID: 39172010. (UPSIT)
• Kim DH, Stybayeva G, Hwang SH. Comparative Effectiveness of Dupilumab Versus Sinus Surgery for Chronic Rhinosinusitis With Polyps: Systematic Review and a Meta-Analysis. Am J Rhinol Allergy. 2024 Aug 16:19458924241272978. doi: 10.1177/19458924241272978. Epub ahead of print. PMID: 39149992. (UPSIT)
• Hopkins C, Han JK, Fokkens W, Wagenmann M, Guyot P, Khan AH, Nash S, Wang Z, Xu Y, Msihid J, Neupane B, Nag A, Bachert C. Dupilumab versus mepolizumab for chronic rhinosinusitis with nasal polyposis: an indirect treatment comparison. J Allergy Clin Immunol Pract. 2024 Sep 24:S2213-2198(24)00941-3. doi: 10.1016/j.jaip.2024.09.015. Epub ahead of print. PMID: 39326524. (UPSIT)
• Lane AP, Mullol J, Hopkins C, Fokkens WJ, Lee SE, Msihid J, Nash S, Sacks H, Borsos K, Kamat S, Rowe PJ, Deniz Y, Jacob-Nara JA. Dupilumab improves sense of smell and clinical outcomes in patients with severe chronic rhinosinusitis with nasal polyps with anosmia. Curr Med Res Opin. 2024 Dec 2:1-11. doi: 10.1080/03007995.2024.2434083. Epub ahead of print. PMID: 39618256. (UPSIT)

2025

• Xu XQ, Zhao QY, Shen Y, Yang YC, Hong SL, Ke X. [Analysis of influencing factors on postoperative olfactory function in patients with chronic rhinosinusitis with nasal polyps]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 Feb 21;60:118-126. Chinese. doi: 10.3760/cma.j.cn115330-20240426-00241. Epub ahead of print. PMID: 39979089. (UPSIT)
• Zheng M, Wu D, Piao Y, Tang J, Quan F, Guan B, Yu H, Zhang X, He G, Yang Y, Wan L, Li X, Liu W, Xu Z, Ye J, Liu W, Song X, Du Y, Xu Y, Chen J, Wang W, Lan F, Wang C, Zhang L. Efficacy and safety of GR1802 in uncontrolled CRSwNP: placebo-controlled phase 2 trial. J Allergy Clin Immunol. 2025 Feb 7:S0091-6749(25)00126-5. doi: 10.1016/j.jaci.2025.01.034. Epub ahead of print. PMID: 39924121. (UPSIT)
• Fujieda S, Pinto JM, Jang DW, Han JK, Mims J, De Corso E, Wagenmann M, Xia C, Plucinak T, Corbett M, Nash S, Radwan A. Baseline disease characteristics by surgery history among patients with chronic rhinosinusitis with nasal polyps (CRSwNP) in the global AROMA registry. Am J Otolaryngol. 2025 Jan 2;46(2):104596. doi: 10.1016/j.amjoto.2024.104596. Epub ahead of print. PMID: 39889367. (UPSIT)
• Oliveira PC, Correia LO, Lopes NMD, Molossi J, Fornazieri MA. Efficacy of Using Photobiomodulation Therapy in Allergic Rhinitis: A Placebo-Controlled Randomized Clinical Trial. Int Forum Allergy Rhinol. 2025 Jan 19. doi: 10.1002/alr.23532. Epub ahead of print. PMID: 39828891. (UPSIT)
• Lanz MJ, Eisenlohr CP, Cepeda LH. Early clinical improvement of anosmia and sinus nitric oxide in chronic rhinosinusitis with nasal polyps subjects treated with dupilumab. Allergy Asthma Proc. 2025 Mar 1;46(2):105-108. doi: 10.2500/aap.2025.46.250004. PMID: 40011990. (UPSIT)
• Lipworth BJ, Greig R, Chan R, Kuo CR. Reappraisal of Biologic Efficacy from Phase 3 Trials in Refractory Chronic Rhinosinusitis and Nasal Polyps. J Allergy Clin Immunol Pract. 2025 May 6:S2213-2198(25)00412-X. doi: 10.1016/j.jaip.2025.04.043. Epub ahead of print. PMID: 40340024. (UPSIT)
• Yu SE, Olonisakin TF, Moore JA, Chiang S, Lee SE. The Association of TSLP and IL-4 with Patient-Reported Outcome Measures in Chronic Rhinosinusitis with Nasal Polyps. Am J Rhinol Allergy. 2025 Mar;39(2):118-127. doi: 10.1177/19458924241311354. Epub 2025 Jan 10. PMID: 39791191. (UPSIT)
• Stihl C, Dombrowski T, Weiss BG, Spiegel JL, Guertler A, Ihler F, Freytag S, Bertlich I, Gröger M, Oppel E, Bertlich M. Real life data with a six months follow-up from dietary interventions, biologic therapy and functional endoscopic surgery (FESS) in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Medicine (Baltimore). 2025 Aug 8;104(32):e43714. doi: 10.1097/MD.0000000000043714. PMID: 40797394; PMCID: PMC12338204. (B-SIT)
• Patel D, Morris JS, Acharya V, Andrews P. Olfactory outcomes following biological therapy in chronic rhinosinusitis: a systematic review and meta-analysis. Rhinology. 2025 Aug 10. doi: 10.4193/Rhin24.573. Epub ahead of print. PMID: 40783912. (UPSIT)
• De Corso E, Canonica GW, Heffler E, Springer M, Grzegorzek T, Viana M, Horváth Z, Mullol J, Gevaert P, Michel J, Peters AT, Wagenmann M, Zaghloul S, Zhang M, Corbett M, Nash S, Angello JT, Radwan A, Deniz Y, Martin A, Hellings PW. Dupilumab versus omalizumab in patients with chronic rhinosinusitis with nasal polyps and coexisting asthma (EVEREST): a multicentre, randomised, double-blind, head-to-head phase 4 trial. Lancet Respir Med. 2025 Sep 28:S2213-2600(25)00287-5. doi: 10.1016/S2213-2600(25)00287-5. Epub ahead of print. PMID: 41033334. (UPSIT)
• Desrosiers M, Nash S, Lane A, Lee SE, De Corso E, Xia C, Corbett M, Radwan A, Rowe PJ, Deniz Y. Peak Nasal Inspiratory Flow and the Association with Nasal Obstruction in Patients with Severe CRSwNP from the SINUS-24/-52 Studies. Adv Ther. 2025 Sep 27. doi: 10.1007/s12325-025-03378-2. Epub ahead of print. PMID: 41014486. (UPSIT)
• Safia A, Khater A, Abd Elhadi U, Merchavy S, Karam M. Optimizing Biologic Treatment Selection in Chronic Rhinosinusitis with Nasal Polyps: A Network Meta-Analysis of Efficacy and Safety Across 22 RCTs. Pharmaceuticals (Basel). 2025 Sep 28;18(10):1455. doi: 10.3390/ph18101455. PMID: 41155574. (UPSIT)
• Lin WC, Wang JJ, Jiang RS. Effect of Functional Endoscopic Sinus Surgery on Eustachian Tube Function. Laryngoscope. 2025 Dec 1. doi: 10.1002/lary.70294. Epub ahead of print. PMID: 41327812. (UPSIT-TC)
• Xu X, Lin J, Luo M, Wu Q. Which Is the Best Biologic for Nasal Polyps: An Updated Network Meta-Analysis. Clin Transl Allergy. 2025 Nov;15(11):e70114. doi: 10.1002/clt2.70114. PMID: 41178615; PMCID: PMC12580786. (UPSIT)
• Ali S, Johnson AO, Villanueva M, Im EY, Justice JM, Chapurin N, Lobo BC, Mulligan JK, Atkinson C. Complement activation correlates with impaired olfactory function in patients with chronic rhinosinusitis with nasal polyps. Chem Senses. 2025 Dec 2:bjaf061. doi: 10.1093/chemse/bjaf061. Epub ahead of print. PMID: 41329167. (UPSIT)
• Liu CM, Fischer JL, Lee MJ, Mace JC, Kimple AJ, Markarian K, Alt JA, Bodner TE, Chowdhury NI, Chung SY, Eshaghian PH, Gao YA, Getz AE, Hwang PH, Khanwalkar A, Lee JT, Li DA, Norris M, Nayak JV, Overdevest JB, Owens C, Patel ZM, Pappas LE, Poch K, Schlosser RJ, Smith KA, Smith TL, Soler ZM, Suh JD, Turner GA, Wang MB, Taylor-Cousar JL, Saavedra MT, Beswick DM. Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis. Laryngoscope. 2025 Jul;135(7):2476-2488. doi: 10.1002/lary.32155. Epub 2025 Mar 29. PMID: 40156369; PMCID: PMC12230906. (UPSIT)

2026

• Mullol J, Han JK, Laidlaw TM, Hopkins C, Peters AT, Pfaar O, Desrosiers M, Lee SE, Lane AP, Chen C, Chon Y, Ponnarambil SS, Foster A, Lindsley AW, Ambrose CS. Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT). Int Forum Allergy Rhinol. 2026 Jan 6. doi: 10.1002/alr.70090. Epub ahead of print. PMID: 41493192. (UPSIT)
• Park AC, Gleason BN, Stein E, Ghadersohi S, Kato A, Shintani-Smith S, Conley DB, Welch KC, Kern RC, Tan BK. Appropriate Medical Therapy Primarily Modifies Type 2 and Severity Biomarkers in Chronic Rhinosinusitis. Int Forum Allergy Rhinol. 2026 Jan 29. doi: 10.1002/alr.70105. Epub ahead of print. PMID: 41609389. (B-SIT)
• Wang X, Ren P, He H, Zhao J, Xin Y, Wang H, Ren X, Zhu K, Chen J. Targeted biologics for chronic rhinosinusitis with nasal polyps: efficacy and safety comparison of eight monoclonal antibodies via network meta-analysis. Rhinology. 2026 Jan 23. doi: 10.4193/Rhin25.395. Epub ahead of print. PMID: 41574646. (UPSIT)
• Brunson JC, Patel A, Ali S, Villanueva M, Justice JM, Lobo BC, Chapurin N, Atkinson C, Mulligan JK. Use of Machine Learning and 71-Plex Immune Mediator Analysis to Identify Nasal Mucus Biomarkers Associated With Olfactory Loss in Patients with CRSwNP. Am J Rhinol Allergy. 2026 Feb 16:19458924261418539. doi: 10.1177/19458924261418539. Epub ahead of print. PMID: 41699443. (UPSIT)

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